All substances that may need to be represented in the context of health care related activities. This value set is quite broad in coverage and includes concepts that may never be needed in a health care activity event, particularly the included SNOMED CT concepts. The code system-specific value sets in this grouping value set are intended to provide broad coverage of all kinds of agents, but the expectation for use is that the chosen concept identifier for a substance should be appropriately specific and drawn from the appropriate code system as noted: prescribable medications should use RXNORM concepts, more specific drugs and chemicals should be represented using UNII concepts, and any substances not found in either of those two code systems, should use the appropriate SNOMED CT concept. This overarching grouping value set is intended to support identification of prescribable medications, foods, general substances and environmental entities.
Value set intensionally defined as a GROUPING made up of: Value Set: Medication Clinical Drug (2.16.840.1.113762.1.4.1010.4) (RxNorm generic and brand codes); Value Set: Unique Ingredient Identifier - Complete Set (2.16.840.1.113883.3.88.12.80.20) (UNII codes); Value Set: Substance Other Than Clinical Drug (2.16.840.1.113762.1.4.1010.9) (SNOMED CT codes).

Valueset Source: https://vsac.nlm.nih.gov/

Priority order for concept determination is RXNORM, UNII, SNOMED CT. Actually a grouper of groupers: GROUPING value set made up of: UNION( Value set: Medication Clinical Drug OID: 2.16.840.1.113762.1.4.1010.4 Value set: Substance Other Than Clinical Drug OID: 2.16.840.1.113762.1.4.1010.9 )

Purpose
Clinical Focus Clinical Focus:Any substance that can be ordered or is included in a clinical record. This is not restricted to medications.

Data Element Scope Data Element Scope.:Clinical Substance ManufacturedProduct/manufacturedMaterial/code/translation/

Inclusion Criteria Inclusion Criteria.:As defined in grouped value sets

Exclusion Criteria Exclusion Criteria.:No drug classes"