Autosomal recessive hereditary disorder
Cardiac arrhythmia associated with genetic disorder
Cardiovascular system hereditary disorder
Chronic heart disease
Chronic intestinal pseudo-obstruction
Digestive system hereditary disorder
Sick sinus syndrome
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Chronic atrial and intestinal dysrhythmia (disorder)
Chronic atrial and intestinal dysrhythmia
CAID (chronic atrial and intestinal dysrhythmia) syndrome
Syndrome with characteristics of sick sinus syndrome and intestinal pseudo-obstruction. The heart and digestive issues develop at the same time, usually by age 20. The syndrome is caused by mutations in the SGO1 gene. This gene provides instructions for making part of a protein complex cohesin. This protein complex helps control the placement of chromosomes during cell division. Research suggests that SGO1 gene mutations may result in a cohesin complex that is less able to hold sister chromatids together, resulting in decreased chromosomal stability during cell division. This instability is thought to cause senescence of cells in the intestinal muscle and in the sinoatrial node, resulting in problems maintaining proper rhythmic movements of the heart and intestines.
chronische atriale en intestinale dysritmie
CAID-syndroom
Id720507006
StatusPrimitive
Clinical courseChronic
Finding siteStructure of sinoatrial node
Associated morphologyPseudo-obstruction
Finding siteIntestinal structure
Finding siteAtrial structure
ICD-10 complex map reference set
TargetK59.8
RuleTRUE
AdviceALWAYS K59.8
CorrelationSNOMED CT source code to target map code correlation not specified
TargetI49.5
RuleTRUE
AdviceALWAYS I49.5
CorrelationSNOMED CT source code to target map code correlation not specified