| Hyperinsulinism due to short chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency (disorder) |
| Hyperinsulinism due to short chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency |
| Hyperinsulinism due to short chain 3-hydroxylacyl-CoA dehydrogenase deficiency
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| A mitochondrial fatty acid oxidation disorder characterized by hyperinsulinemic hypoglycemia with seizures, and in one case fulminant hepatic failure. Less than 10 cases have been reported to date. The disease can present in infancy or early childhood. It presents with the manifestations of hyperinsulinemic hypoglycemia with vomiting, lethargy and seizures. Complications include coma and sudden death. It has responded well to diazoxide. It is caused by a mutation in the HADH gene (4q22-q26) encoding the SCHAD protein that has a dual function both as an enzyme and an inhibitor of glutamate dehydrogenase. The mode of inheritance is autosomal recessive. |
| hyperinsulinisme door deficiëntie van korte-keten-3-hydroxy-acyl-coenzym-A-dehydrogenase |
| hyperinsulinisme door korte-keten-3-hydroxy-acyl-coenzym-A-dehydrogenasedeficiëntie
hyperinsulinisme door korte-keten-3-hydroxyacyl-CoA-dehydrogenasedeficiëntie
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