Abnormal granulation tissue	Abnormal granulation tissue	Congenital junctional epidermolysis bullosa	Congenital junctional epidermolysis bullosa
\|	\|	\|	\|

Laryngo-onycho-cutaneous syndrome (disorder)
	Laryngo-onycho-cutaneous syndrome
	LOC syndrome Laryngoonychocutaneous syndrome Shabbir syndrome LOGIC syndrome
	LOC syndrome is a subtype of junctional epidermolysis bullosa with characteristics of an altered cry in the neonatal period and aberrant production of granulation tissue in particular affecting the upper airway tract, conjunctiva and periungual/subungual sites. Fewer than 50 cases have been reported to date, mostly in consanguineous families from the Punjabi region of Pakistan and India. The condition is present at birth. The condition is associated with mutations in the alpha-3 chain of laminin-332 (LAMA3). Follows an autosomal recessive pattern of inheritance. Prognosis is poor.
	laryngo-onycho-cutaan syndroom
	LOC-syndroom

Id	722675000
Status	Primitive

Associated morphology	Hypertrophic granulation tissue
Finding site	Skin structure
Occurrence	Congenital
Pathological process	Pathological developmental process

Associated morphology	Epidermolysis
Finding site	Skin structure
Occurrence	Congenital
Pathological process	Pathological developmental process

DHD Diagnosis thesaurus reference set

ICD-10 complex map reference set

Target	Q81.8
Rule	TRUE
Advice	ALWAYS Q81.8 \| POSSIBLE REQUIREMENT FOR ADDITIONAL CODE TO FULLY DESCRIBE DISEASE OR CONDITION
Correlation	SNOMED CT source code to target map code correlation not specified