Autosomal dominant hereditary spastic paraplegia	Chronic disease of genitourinary system	Chronic mental disorder	Complicated hereditary spastic paraplegia	Developmental hereditary disorder	Hereditary disorder of endocrine system	Intellectual disability	Precocious puberty	Reproductive system hereditary disorder
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Spastic paraplegia with precocious puberty syndrome (disorder)
	Spastic paraplegia with precocious puberty syndrome
	Syndrome with characteristics of precocious puberty (due to Leydig cell hyperplasia), progressive spastic paraplegia and intellectual deficit. It has been described in two brothers. The fact that other family members displayed brisk reflexes and dysarthria suggested autosomal dominant inheritance with variable expression.
	syndroom van spastische paraplegie en pubertas praecox

Id	732958004
Status	Primitive

Associated morphology	Maturation acceleration
Finding site	Gonadal endocrine structure
Pathological process	Pathological developmental process

Clinical course

Associated morphology	Degenerative abnormality
Finding site	Spinal cord structure

Finding site

Lower limb structure

DHD Diagnosis thesaurus reference set

ICD-10 complex map reference set

Target	G11.4
Rule	TRUE
Advice	ALWAYS G11.4
Correlation	SNOMED CT source code to target map code correlation not specified

Target	E30.1
Rule	TRUE
Advice	ALWAYS E30.1
Correlation	SNOMED CT source code to target map code correlation not specified