Autosomal hereditary disorder	Developmental hereditary disorder	Ectrodactyly	Holoprosencephaly sequence	Multiple malformation syndrome with limb defect as major feature
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Holoprosencephaly, ectrodactyly, cleft lip, cleft palate syndrome (disorder)
	Hartsfield syndrome
	Hartsfield Bixler Demyer syndrome Holoprosencephaly, ectrodactyly, cleft lip, cleft palate syndrome
	A rare disease with characteristics of holoprosencephaly and ectrodactyly. Holoprosencephaly occurs during early fetal development with failure of the brain to divide into the left and right hemisphere. In the most severe forms of holoprosencephaly, the brain does not divide at all. These affected individuals have cyclopia and proboscis located above the eye. Most babies with severe holoprosencephaly die before birth or soon after. Other manifestations include malfunctioning pituitary, seizures, feeding difficulties, developmental delay and problems regulating body temperature and sleep pattern. Some affected individuals have distinctive facial features, including hypertelorism, hypotelorism, cleft lip, cleft palate. Can be caused by mutations in the FGFR1 gene.
	syndroom van holoprosencefalie, ectrodactylie en cheilopalatoschisis
	syndroom van holoprosencefalie, ectrodactylie, gespleten gehemelte en gespleten lip syndroom van Hartsfield

Id	766032007
Status	Primitive

Associated morphology	Morphologically abnormal structure
Finding site	Head structure
Occurrence	Congenital
Pathological process	Pathological developmental process

Associated morphology	Absence
Finding site	Entire digit
Occurrence	Congenital
Pathological process	Pathological developmental process

DHD Diagnosis thesaurus reference set

ICD-10 complex map reference set

Target	Q87.8
Rule	TRUE
Advice	ALWAYS Q87.8 \| POSSIBLE REQUIREMENT FOR ADDITIONAL CODE TO FULLY DESCRIBE DISEASE OR CONDITION
Correlation	SNOMED CT source code to target map code correlation not specified